Sevelamer is a phosphate binder commonly used in patients with end-stage renal disease that has been linked to severe gastrointestinal inflammation and perforation[1]. This case series identified 12 patients with biopsy-proven sevelamer-induced gastrointestinal disease over 5 years at a large urban hospital[1].

Key findings:

The authors conclude that sevelamer-induced gastrointestinal disease has a broad range of presentations and severity[1]. Clinicians should be aware of this increasingly recognized condition, particularly in patients with risk factors like impaired GI motility or mucosal integrity[1]. More research is needed on the time course of disease development and resolution after stopping the drug[1].


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